The Drug Use Among Young Indians: Epidemiology and Prediction study is an annual surveillance effort assessing the levels and patterns of substance use among American Indian (AI) adolescents attending schools on or near reservations. In addition to annual epidemiology of substance use, data pertaining to the normative environment for adolescent substance use were also obtained. For this data collection data comes from annual in-school surveys completed between the years 2001 to 2006, and 2009 to 2013. Students completed the surveys at school during a specified class period. The dataset contains 527 variables for 16,590 students in grades 7 to 12.